Active Immunization Against Poliomyelitis

Active Immunization against Poliomyelitis

1. A single intracutaneous inoculation with a subinfective dose of the virus of poliomyelitis produces considerable immunity. 2. Virus-serum combinations produce an appreciable immunity, providing just sufficient serum is used to protect the animal from paralysis. If there is an excess of serum, the degree of immunity is considerably reduced.

Active Immunization against Poliomyelitis in Monkeys

1. A combination of poliomyelitis virus and specific human serum is effective for the production of active immunity. 2. For each gram of active virus given intradermally as an emulsion, 6 cc. of human immune serum, injected subcutaneously, was required in our experiments to protect a monkey from paralysis. Some degree of active immunity was induced. 3. Immunity, without symptom of the disease, ...

Experiments on Active Immunization against Experimental Poliomyelitis

The results obtained in this investigation indicate that poliomyelitis virus treated with tannin, sodium ricinoleate, or formalin does not constitute a satisfactory immunizing agent in monkeys against the experimental disease.

Intradermal versus Subcutaneous Immunization of Monkeys against Poliomyelitis

1. The introduction of considerable amounts of living, active poliomyelitis virus into the skin and subcutaneous tissue of monkeys protects the animals against intracerebral inoculations of similar virus material. 2. The degree of protection conferred by intradermal is greater than by subcutaneous injection. 3. During intradermal and subcutaneous inoculations, no local or general pathological s...

The expanded programme in immunization against measles and poliomyelitis, Iran's Experience.